Loading...

Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase

BACKGROUND: Ceramide is an important second messenger that has diverse cellular and biological effect. It is a specific and potent inducer of apoptosis and suppressor of cell growth. In leukemia, chemoresistance generally developed due to deregulated ceramide metabolism. In combinatorial treatment s...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Mondal, Susmita, Mandal, Chandan, Sangwan, Rajender, Chandra, Sarmila, Mandal, Chitra
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949798/
https://ncbi.nlm.nih.gov/pubmed/20836852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-239
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!