Doxorubicin downregulates cell surface B7-H1 expression and upregulates its nuclear expression in breast cancer cells: role of B7-H1 as an anti-apoptotic molecule

INTRODUCTION: B7-H1 (PD-L1, CD274) is a T cell inhibitory molecule expressed in many types of cancer, leading to immune escape of tumor cells. Indeed, in previous reports we have shown an association of B7-H1 expression with high-risk breast cancer patients. METHODS: In the current study, we used im...

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Detalhes bibliográficos
Main Authors: Ghebeh, Hazem, Lehe, Cynthia, Barhoush, Eman, Al-Romaih, Khaldoon, Tulbah, Asma, Al-Alwan, Monther, Hendrayani, Siti-Faujiah, Manogaran, Pulicat, Alaiya, Ayodele, Al-Tweigeri, Taher, Aboussekhra, Abdelilah, Dermime, Said
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949635/
https://ncbi.nlm.nih.gov/pubmed/20626886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2605
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