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CHEK2 represses breast stromal fibroblasts and their paracrine tumor-promoting effects through suppressing SDF-1 and IL-6

BACKGROUND: Active fibroblasts, the predominant and the most active cells of breast cancer stroma, are responsible for tumor growth and spread. However, the molecular mediators and pathways responsible for stromal fibroblast activation, and their paracrine pro-carcinogenic effects are still not well...

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Dettagli Bibliografici
Pubblicato in:BMC Cancer
Autori principali: Al-Rakan, Maha A., Hendrayani, Siti-Faujiah, Aboussekhra, Abdelilah
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970236/
https://ncbi.nlm.nih.gov/pubmed/27484185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2614-5
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