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CHEK2 represses breast stromal fibroblasts and their paracrine tumor-promoting effects through suppressing SDF-1 and IL-6

BACKGROUND: Active fibroblasts, the predominant and the most active cells of breast cancer stroma, are responsible for tumor growth and spread. However, the molecular mediators and pathways responsible for stromal fibroblast activation, and their paracrine pro-carcinogenic effects are still not well...

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Publicado en:BMC Cancer
Autores principales: Al-Rakan, Maha A., Hendrayani, Siti-Faujiah, Aboussekhra, Abdelilah
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970236/
https://ncbi.nlm.nih.gov/pubmed/27484185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2614-5
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