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CHEK2 represses breast stromal fibroblasts and their paracrine tumor-promoting effects through suppressing SDF-1 and IL-6

BACKGROUND: Active fibroblasts, the predominant and the most active cells of breast cancer stroma, are responsible for tumor growth and spread. However, the molecular mediators and pathways responsible for stromal fibroblast activation, and their paracrine pro-carcinogenic effects are still not well...

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Publicat a:BMC Cancer
Autors principals: Al-Rakan, Maha A., Hendrayani, Siti-Faujiah, Aboussekhra, Abdelilah
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970236/
https://ncbi.nlm.nih.gov/pubmed/27484185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2614-5
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