Depletion of Werner helicase results in mitotic hyperrecombination and pleiotropic homologous and nonhomologous recombination phenotypes

Werner syndrome (WS) is a rare, segmental progeroid syndrome caused by defects in the WRN gene, which encodes a RecQ helicase. WRN has roles in many aspects of DNA metabolism including DNA repair and recombination. In this study, we exploited two different recombination assays previously used to des...

Full description

Saved in:
Bibliographic Details
Main Authors: Rahn, Jennifer J., Lowery, Megan P., Della-Coletta, Luis, Adair, Gerald M., Nairn, Rodney S.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949496/
https://ncbi.nlm.nih.gov/pubmed/20708636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2010.08.001
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items