Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke

Recent studies showed that soluble annexin A2 dramatically increases tissue plasminogen activator (tPA)-mediated plasmin generation in vitro, and reduces thrombus formation in vivo. Here, we hypothesize that combining annexin A2 with tPA can significantly enhance thrombolysis efficacy, so that lower...

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Detalhes bibliográficos
Main Authors: Zhu, Haihao, Fan, Xiang, Yu, Zhanyang, Liu, Jianxiang, Murata, Yoshihiro, Lu, Jie, Zhao, Song, Hajjar, Katherine A, Lo, Eng H, Wang, Xiaoying
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949213/
https://ncbi.nlm.nih.gov/pubmed/20068577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2009.279
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