Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus and nucleus accumbens in old rats after chronic donepezil administration

In Alzheimer's disease brains morphological changes in the dendrites of pyramidal neurons of the prefrontal cortex (PFC) and hippocampus have been observed. These changes are particularly reflected in the decrement of both the dendritic tree and spine number. Donepezil is a potent and selective...

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Autores principales: Alcantara-Gonzalez, Faviola, Juarez, Ismael, Solis, Oscar, Martinez-Tellez, Isaura, Camacho-Abrego, Israel, Masliah, Eliezer, Mena, Raul, Flores, Gonzalo
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Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948955/
https://ncbi.nlm.nih.gov/pubmed/20336627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/syn.20787
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spelling pubmed-29489552011-10-01 Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus and nucleus accumbens in old rats after chronic donepezil administration Alcantara-Gonzalez, Faviola Juarez, Ismael Solis, Oscar Martinez-Tellez, Isaura Camacho-Abrego, Israel Masliah, Eliezer Mena, Raul Flores, Gonzalo Synapse Article In Alzheimer's disease brains morphological changes in the dendrites of pyramidal neurons of the prefrontal cortex (PFC) and hippocampus have been observed. These changes are particularly reflected in the decrement of both the dendritic tree and spine number. Donepezil is a potent and selective acetylcholinesterase inhibitor used in the treatment of Alzheimer's disease. We have studied the effect of oral administration of this drug on the morphology of neuronal cells from the brain of aged rats. We examined dendrites of pyramidal neurons of the PFC, dorsal or ventral hippocampus and medium spiny neurons of the nucleus accumbens (NAcc). Donepezil (1 mg/Kg, vo) was administrated every day for 60 days to rats aged 10 and 18 months. Dendritic morphology was studied by the Golgi-Cox stain procedure followed by Sholl analysis at 12 and 20 months ages, respectively. In all Donepezil treated-rats a significant increment of the dendritic spines number in pyramidal neurons of the PFC, dorsal hippocampus was observed. However, pyramidal neurons of the ventral hippocampus and medium spiny cells of the NAcc only showed an increase in the number of their spines in 12 months old-rats. Our results suggest that Donepezil prevents the alterations of the neuronal dendrite morphology caused by aging. 2010-10 /pmc/articles/PMC2948955/ /pubmed/20336627 http://dx.doi.org/10.1002/syn.20787 Text en
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Article
spellingShingle Article
Alcantara-Gonzalez, Faviola
Juarez, Ismael
Solis, Oscar
Martinez-Tellez, Isaura
Camacho-Abrego, Israel
Masliah, Eliezer
Mena, Raul
Flores, Gonzalo
Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus and nucleus accumbens in old rats after chronic donepezil administration
description In Alzheimer's disease brains morphological changes in the dendrites of pyramidal neurons of the prefrontal cortex (PFC) and hippocampus have been observed. These changes are particularly reflected in the decrement of both the dendritic tree and spine number. Donepezil is a potent and selective acetylcholinesterase inhibitor used in the treatment of Alzheimer's disease. We have studied the effect of oral administration of this drug on the morphology of neuronal cells from the brain of aged rats. We examined dendrites of pyramidal neurons of the PFC, dorsal or ventral hippocampus and medium spiny neurons of the nucleus accumbens (NAcc). Donepezil (1 mg/Kg, vo) was administrated every day for 60 days to rats aged 10 and 18 months. Dendritic morphology was studied by the Golgi-Cox stain procedure followed by Sholl analysis at 12 and 20 months ages, respectively. In all Donepezil treated-rats a significant increment of the dendritic spines number in pyramidal neurons of the PFC, dorsal hippocampus was observed. However, pyramidal neurons of the ventral hippocampus and medium spiny cells of the NAcc only showed an increase in the number of their spines in 12 months old-rats. Our results suggest that Donepezil prevents the alterations of the neuronal dendrite morphology caused by aging.
author Alcantara-Gonzalez, Faviola
Juarez, Ismael
Solis, Oscar
Martinez-Tellez, Isaura
Camacho-Abrego, Israel
Masliah, Eliezer
Mena, Raul
Flores, Gonzalo
author_facet Alcantara-Gonzalez, Faviola
Juarez, Ismael
Solis, Oscar
Martinez-Tellez, Isaura
Camacho-Abrego, Israel
Masliah, Eliezer
Mena, Raul
Flores, Gonzalo
author_sort Alcantara-Gonzalez, Faviola
title Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus and nucleus accumbens in old rats after chronic donepezil administration
title_short Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus and nucleus accumbens in old rats after chronic donepezil administration
title_full Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus and nucleus accumbens in old rats after chronic donepezil administration
title_fullStr Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus and nucleus accumbens in old rats after chronic donepezil administration
title_full_unstemmed Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus and nucleus accumbens in old rats after chronic donepezil administration
title_sort enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus and nucleus accumbens in old rats after chronic donepezil administration
publishDate 2010
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2948955/
https://ncbi.nlm.nih.gov/pubmed/20336627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/syn.20787
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