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Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
There is a long-standing paradox that N-methyl-D-aspartate receptors (NMDARs) can both promote neuronal health and kill neurons. Recent studies show that NMDAR-induced responses depend on the receptor location: stimulation of synaptic NMDARs, acting primarily through nuclear Ca(2+) signaling, leads...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2948541/ https://ncbi.nlm.nih.gov/pubmed/20842175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrn2911 |
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