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EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with Designed Ankyrin Repeat Proteins

Specific delivery to tumors and efficient cellular uptake of nucleic acids remain major challenges for gene-targeted cancer therapies. Here we report the use of a Designed Ankyrin Repeat Protein (DARPin) specific for the Epithelial Cell Adhesion Molecule (EpCAM) as carrier for siRNA complementary to...

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Autors principals: Winkler, Johannes, Martin-Killias, Patricia, Plückthun, Andreas, Zangemeister-Wittke, Uwe
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948527/
https://ncbi.nlm.nih.gov/pubmed/19723880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0402
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