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EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with Designed Ankyrin Repeat Proteins
Specific delivery to tumors and efficient cellular uptake of nucleic acids remain major challenges for gene-targeted cancer therapies. Here we report the use of a Designed Ankyrin Repeat Protein (DARPin) specific for the Epithelial Cell Adhesion Molecule (EpCAM) as carrier for siRNA complementary to...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2948527/ https://ncbi.nlm.nih.gov/pubmed/19723880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0402 |
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