Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis

BACKGROUND: Cdx4 is a homeobox gene essential for normal blood formation during embryonic development in the zebrafish, through activation of posterior Hox genes. However, its role in adult mammalian hematopoiesis has not been extensively studied and its requirement in leukemia associated with Hox g...

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Autores principales: Koo, Sumin, Huntly, Brian J., Wang, Yuan, Chen, Jing, Brumme, Kristina, Ball, Brian, McKinney-Freeman, Shannon L., Yabuuchi, Akiko, Scholl, Claudia, Bansal, Dimple, Zon, Leonard I., Fröhling, Stefan, Daley, George Q., Gilliland, D. Gary, Mercher, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: Ferrata Storti Foundation 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948088/
https://ncbi.nlm.nih.gov/pubmed/20494928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.023168
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