Structure of the Extracellular Portion of CD46 Provides Insights into Its Interactions with Complement Proteins and Pathogens

The human membrane cofactor protein (MCP, CD46) is a central component of the innate immune system. CD46 protects autologous cells from complement attack by binding to complement proteins C3b and C4b and serving as a cofactor for their cleavage. Recent data show that CD46 also plays a role in mediat...

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Bibliografiske detaljer
Main Authors: Persson, B. David, Schmitz, Nikolaus B., Santiago, César, Zocher, Georg, Larvie, Mykol, Scheu, Ulrike, Casasnovas, José M., Stehle, Thilo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947992/
https://ncbi.nlm.nih.gov/pubmed/20941397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001122
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