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A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
Autophagy is an intracellular turnover pathway. It has special relevance for neurodegenerative proteinopathies, such as Alzheimer disease, Parkinson disease, and Huntington disease (HD), which are characterized by the accumulation of misfolded proteins. Although induction of autophagy enhances clear...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2947884/ https://ncbi.nlm.nih.gov/pubmed/20833817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004498107 |
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