Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

Androgen receptor (AR) splice variants lacking the ligand binding domain (ARVs), originally isolated from prostate cancer cell lines derived from a single patient, are detected in normal and malignant human prostate tissue, with the highest levels observed in late stage, castration-resistant prostat...

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Autors principals: Watson, Philip A., Chen, Yinan F., Balbas, Minna D., Wongvipat, John, Socci, Nicholas D., Viale, Agnes, Kim, Kwanghee, Sawyers, Charles L.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947883/
https://ncbi.nlm.nih.gov/pubmed/20823238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012443107
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