Equitoxic Doses of 5-Azacytidine and 5-Aza-2′Deoxycytidine Induce Diverse Immediate and Overlapping Heritable Changes in the Transcriptome

BACKGROUND: The hypomethylating agent 5-Azacytidine (5-Aza-CR) is the first drug to prolong overall survival in patients with myelodysplastic syndrome (MDS). Surprisingly, the deoxyribonucleoside analog 5-Aza-2′deoxycytidine (5-Aza-CdR) did not have a similar effect on survival in a large clinical t...

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Detalhes bibliográficos
Main Authors: Qiu, Xiangning, Hother, Christoffer, Ralfkiær, Ulrik M., Søgaard, Alexandra, Lu, Qianjin, Workman, Christopher T., Liang, Gangning, Jones, Peter A., Grønbæk, Kirsten
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947512/
https://ncbi.nlm.nih.gov/pubmed/20927380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012994
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