Sprouty Proteins Inhibit Receptor-mediated Activation of Phosphatidylinositol-specific Phospholipase C

Sprouty (Spry) proteins are negative regulators of receptor tyrosine kinase signaling; however, their exact mechanism of action remains incompletely understood. We identified phosphatidylinositol-specific phospholipase C (PLC)-γ as a partner of the Spry1 and Spry2 proteins. Spry–PLCγ interaction was...

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Main Authors: Akbulut, Simge, Reddi, Alagarsamy L., Aggarwal, Priya, Ambardekar, Charuta, Canciani, Barbara, Kim, Marianne K.H., Hix, Laura, Vilimas, Tomas, Mason, Jacqueline, Basson, M. Albert, Lovatt, Matthew, Powell, Jonathan, Collins, Samuel, Quatela, Steven, Phillips, Mark, Licht, Jonathan D.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947483/
https://ncbi.nlm.nih.gov/pubmed/20719962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-02-0123
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