Small Molecule Inhibition of HIV-1–Induced MHC-I Down-Regulation Identifies a Temporally Regulated Switch in Nef Action

HIV-1 Nef triggers down-regulation of cell-surface MHC-I by assembling a Src family kinase (SFK)-ZAP-70/Syk-PI3K cascade. Here, we report that chemical disruption of the Nef-SFK interaction with the small molecule inhibitor 2c blocks assembly of the multi-kinase complex and represses HIV-1–mediated...

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Autors principals: Dikeakos, Jimmy D., Atkins, Katelyn M., Thomas, Laurel, Emert-Sedlak, Lori, Byeon, In-Ja L., Jung, Jinwon, Ahn, Jinwoo, Wortman, Matthew D., Kukull, Ben, Saito, Masumichi, Koizumi, Hirokazu, Williamson, Danielle M., Hiyoshi, Masateru, Barklis, Eric, Takiguchi, Masafumi, Suzu, Shinya, Gronenborn, Angela M., Smithgall, Thomas E., Thomas, Gary
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2010
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947465/
https://ncbi.nlm.nih.gov/pubmed/20702582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-05-0470
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