Disruption of the Fgf2 Gene Activates the Adipogenic and Suppresses the Osteogenic Program in Mesenchymal Marrow Stromal Stem Cells

Here we determine the Fibroblast Growth Factor-2 (FGF2) dependency of the time course of changes in bone mass in female mice. This study extends our earlier reports that knockout of the FGF2 gene (Fgf2) caused low turnover bone loss in Fgf2(−/−) male mice by examining bone loss with age in Fgf2(−/−)...

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Autori principali: Xiao, Liping, Sobue, Takanori, Eisliger, Alycia, Kronenberg, Mark. S, Coffin, J. Douglas, Doetschman, Thomas, Hurley, Marja M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947437/
https://ncbi.nlm.nih.gov/pubmed/20510392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2010.05.021
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