Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis

The antithrombotic surface of endothelium is regulated in a coordinated manner. Tissue factor pathway inhibitor (TFPI) localized at the endothelial cell surface regulates the production of FXa by inhibiting the TF/VIIa complex. Systemic homozygotic deletion of the first Kunitz (K1) domain of TFPI re...

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Detalhes bibliográficos
Main Authors: White, Thomas A., Johnson, Tucker, Zarzhevsky, Natalia, Tom, Cindy, Delacroix, Sinny, Holroyd, Eric W., Maroney, Susan A., Singh, Ripudamanjit, Pan, Shuchong, Fay, William P., van Deursen, Jan, Mast, Alan E., Sandhu, Gurpreet S., Simari, Robert D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947398/
https://ncbi.nlm.nih.gov/pubmed/20516367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-250910
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