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GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice
Leukocyte adhesion in the microvasculature influences blood rheology and plays a key role in vaso-occlusive manifestations of sickle cell disease. Notably, polymorphonuclear neutrophils (PMNs) can capture circulating sickle red blood cells (sRBCs) in inflamed venules, leading to critical reduction i...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2947397/ https://ncbi.nlm.nih.gov/pubmed/20508165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-260513 |
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