Cross-priming CD8(+) T cells by targeting antigens to human dendritic cells through DCIR

We evaluated human CD8(+) T-cell responses generated by targeting antigens to dendritic cells (DCs) through various lectin receptors. We found the immunoreceptor tyrosine-based inhibitory motif-containing DC immunoreceptor (DCIR) to mediate potent cross-presentation. A single exposure to a low dose...

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Main Authors: Klechevsky, Eynav, Flamar, Anne-Laure, Cao, Yanying, Blanck, Jean-Philippe, Liu, Maochang, O'Bar, Amy, Agouna-Deciat, Olivier, Klucar, Peter, Thompson-Snipes, LuAnn, Zurawski, Sandra, Reiter, Yoram, Palucka, A. Karolina, Zurawski, Gerard, Banchereau, Jacques
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2010
Teme:
Immunobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947393/
https://ncbi.nlm.nih.gov/pubmed/20530286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-264960
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