TLR8 deficiency leads to autoimmunity in mice

TLRs play an essential role in the induction of immune responses by detecting conserved molecular products of microorganisms. However, the function of TLR8 is largely unknown. In the current study, we investigated the role of TLR8 signaling in immunity in mice. We found that Tlr8(–/–) DCs overexpres...

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Main Authors: Demaria, Olivier, Pagni, Philippe P., Traub, Stephanie, de Gassart, Aude, Branzk, Nora, Murphy, Andrew J., Valenzuela, David M., Yancopoulos, George D., Flavell, Richard A., Alexopoulou, Lena
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947223/
https://ncbi.nlm.nih.gov/pubmed/20811154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42081
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