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Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice
The homeodomain transcription factor pancreatic duodenal homeobox 1 (Pdx1) is a major mediator of insulin transcription and a key regulator of the β cell phenotype. Heterozygous mutations in PDX1 are associated with the development of diabetes in humans. Understanding how Pdx1 expression levels are...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2947215/ https://ncbi.nlm.nih.gov/pubmed/20811152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40440 |
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