A PDX1-ATF transcriptional complex governs β cell survival during stress

OBJECTIVE: Loss of insulin secretion due to failure or death of the insulin secreting β cells is the central cause of diabetes. The cellular response to stress (endoplasmic reticulum (ER), oxidative, inflammatory) is essential to sustain normal β cell function and survival. Pancreatic and duodenal h...

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Bibliografske podrobnosti
izdano v:Mol Metab
Main Authors: Juliana, Christine A., Yang, Juxiang, Cannon, Corey E., Good, Austin L., Haemmerle, Matthew W., Stoffers, Doris A.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2018
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197747/
https://ncbi.nlm.nih.gov/pubmed/30174228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.07.007
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