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A genetically-encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing

TNF-related apoptosis-inducing ligand (TRAIL, Apo2L) has been shown to exhibit potent and specific apoptotic activity against tumor cells. Several TRAIL constructs have been tried in patients and the molecule remains under active clinical investigation. Native and recombinant TRAIL must form a homot...

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Detalhes bibliográficos
Main Authors: Spitzer, Dirk, McDunn, Jonathan E., Plambeck-Suess, Stacey, Goedegebuure, Peter S., Hotchkiss, Richard S., Hawkins, William G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947203/
https://ncbi.nlm.nih.gov/pubmed/20571073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0225
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