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A genetically-encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing
TNF-related apoptosis-inducing ligand (TRAIL, Apo2L) has been shown to exhibit potent and specific apoptotic activity against tumor cells. Several TRAIL constructs have been tried in patients and the molecule remains under active clinical investigation. Native and recombinant TRAIL must form a homot...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2947203/ https://ncbi.nlm.nih.gov/pubmed/20571073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0225 |
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