Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21

The Helicobacter pylori CagA bacterial oncoprotein plays a critical role in gastric carcinogenesis. Upon delivery into epithelial cells, CagA causes loss of polarity and activates aberrant Erk signaling. We show that CagA-induced Erk activation results in senescence and mitogenesis in nonpolarized a...

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Bibliografiske detaljer
Main Authors: Saito, Yasuhiro, Murata-Kamiya, Naoko, Hirayama, Toshiya, Ohba, Yusuke, Hatakeyama, Masanori
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947069/
https://ncbi.nlm.nih.gov/pubmed/20855497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100602
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