Sustained Spindle-Assembly Checkpoint Response Requires De Novo Transcription and Translation of Cyclin B1

BACKGROUND: Microtubule-targeting drugs induce mitotic delay at pro-metaphase by preventing the spindle assembly checkpoint to be satisfied. However, especially after prolonged treatments, cells can escape this arrest in a process called mitotic slippage. The mechanisms underlying the spindle assemb...

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Bibliographic Details
Main Authors: Mena, Ana Lúcia, Lam, Eric W.-F., Chatterjee, Sukalyan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946930/
https://ncbi.nlm.nih.gov/pubmed/20927403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013037
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