Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases

Botulinum neurotoxins (BoNTs) function by delivering a protease to neuronal cells that cleave SNARE proteins and inactivate neurotransmitter exocytosis. Small (14 kDa) binding domains specific for the protease of BoNT serotypes A or B were selected from libraries of heavy chain only antibody domains...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Tremblay, Jacqueline M., Kuo, Chueh-Ling, Abeijon, Claudia, Sepulveda, Jorge, Oyler, George, Hu, Xuebo, Jin, Moonsoo M., Shoemaker, Charles B.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946066/
https://ncbi.nlm.nih.gov/pubmed/20637220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2010.07.003
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker