Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases

Botulinum neurotoxins (BoNTs) function by delivering a protease to neuronal cells that cleave SNARE proteins and inactivate neurotransmitter exocytosis. Small (14 kDa) binding domains specific for the protease of BoNT serotypes A or B were selected from libraries of heavy chain only antibody domains...

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Main Authors: Tremblay, Jacqueline M., Kuo, Chueh-Ling, Abeijon, Claudia, Sepulveda, Jorge, Oyler, George, Hu, Xuebo, Jin, Moonsoo M., Shoemaker, Charles B.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946066/
https://ncbi.nlm.nih.gov/pubmed/20637220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2010.07.003
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