Inhibition of tumour necrosis factor and IL-17 production by leflunomide involves the JAK/STAT pathway

OBJECTIVE: To study the effects of different disease-modifying antirheumatic drugs (DMARD) on different events mediated by IL-15-activated lymphocytes. METHODS: Peripheral blood lymphocytes (PBL) were isolated from healthy donors and activated with IL-15 after exposure to different DMARD: leflunomid...

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Autori principali: González-Alvaro, I, Ortiz, A M, Domínguez-Jiménez, C, Aragón-Bodi, A, Sánchez, B Díaz, Sánchez-Madrid, F
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Group 2008
Soggetti:
Basic and Translational Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946060/
https://ncbi.nlm.nih.gov/pubmed/18957484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2008.096743
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