IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis

BACKGROUND: IL-17A has recently emerged as a potential target that regulates the extensive inflammation and abnormal bone formation observed in ankylosing spondylitis (AS). Blocking IL-17A is expected to inhibit bony ankylosis. Here, we investigated the effects of anti IL-17A agents in AS. METHODS:...

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Vydáno v:Arthritis Res Ther
Hlavní autoři: Jo, Sungsin, Wang, Sung Eun, Lee, Young Lim, Kang, Suman, Lee, Bitnara, Han, Jinil, Sung, Il-Hoon, Park, Ye-Soo, Bae, Sang-Cheol, Kim, Tae-Hwan
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992730/
https://ncbi.nlm.nih.gov/pubmed/29880011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1582-3
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