VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

The cellular and molecular mechanisms by which a tumour cell undergoes metastasis to a predetermined location are largely unknown. Here we demonstrate that bone marrow-derived haematopoietic progenitor cells that express vascular endothelial growth factor receptor 1 (VEGFR1; also known as Flt1) home...

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Main Authors: Kaplan, Rosandra N., Riba, Rebecca D., Zacharoulis, Stergios, Bramley, Anna H., Vincent, Loïc, Costa, Carla, MacDonald, Daniel D., Jin, David K., Shido, Koji, Kerns, Scott A., Zhu, Zhenping, Hicklin, Daniel, Wu, Yan, Port, Jeffrey L., Altorki, Nasser, Port, Elisa R., Ruggero, Davide, Shmelkov, Sergey V., Jensen, Kristian K., Rafii, Shahin, Lyden, David
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945882/
https://ncbi.nlm.nih.gov/pubmed/16341007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature04186
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