Differentiation of human ES and Parkinson’s disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid

The cardinal motor symptoms of Parkinson’s disease (PD) are caused by the vulnerability to dysfunction and degeneration of ventral midbrain (VM) dopaminergic (DA) neurons. A major limitation for experimental studies of current ES/iPS cell differentiation protocols is the lack of VM DA neurons with a...

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Main Authors: Cooper, Oliver, Hargus, Gunnar, Deleidi, Michela, Blak, Alexandra, Osborn, Teresia, Marlow, Elizabeth, Lee, Kristen, Levy, Adam, Perez-Torres, Eduardo, Yow, Alyssa, Isacson, Ole
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945816/
https://ncbi.nlm.nih.gov/pubmed/20603216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2010.06.017
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