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Connecting energy landscapes with experimental rates for aminoacyl-tRNA accommodation in the ribosome
[Image: see text] Using explicit-solvent simulations of the 70S ribosome, the barrier-crossing attempt frequency was calculated for aminoacyl-tRNA elbow-accommodation. In seven individual trajectories (200–300 ns, each), the relaxation time of tRNA structural fluctuations was determined to be ~ 10 n...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945706/ https://ncbi.nlm.nih.gov/pubmed/20806913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja1061399 |
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