NMR and Bioinformatics Discovery of Exosites That Tune Metalloelastase Specificity for Solubilized Elastin and Collagen Triple Helices

The catalytic domain of metalloelastase (matrix metalloproteinase-12 or MMP-12) is unique among MMPs in exerting high proteolytic activity upon fibrils that resist hydrolysis, especially elastin from lungs afflicted with chronic obstructive pulmonary disease or arteries with aneurysms. How does the...

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Bibliographic Details
Main Authors: Palmier, Mark O., Fulcher, Yan G., Bhaskaran, Rajagopalan, Duong, Vinh Q., Fields, Gregg B., Van Doren, Steven R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945583/
https://ncbi.nlm.nih.gov/pubmed/20663866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.136903
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