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Solution Structure of Inhibitor-Free Human Metalloelastase (MMP-12) Indicates an Internal Conformational Adjustment
Macrophage metalloelastase or MMP-12 appears to exacerbate atherosclerosis, emphysema, aortic aneurysm, rheumatoid arthritis, and inflammatory bowel disease. An inactivating E219A mutation, validated by crystallography and NMR spectra, prevents autolysis of MMP-12 and allowed us to determine its NMR...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2813705/ https://ncbi.nlm.nih.gov/pubmed/17997411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.10.028 |
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