Apparent Tradeoff of Higher Activity in MMP-12 for Enhanced Stability and Flexibility in MMP-3

The greater activity of MMP-12 than MMP-3 toward substrates from protein fibrils has been quantified. Why is MMP-12 the more active protease? We looked for behaviors associated with the higher activity of MMP-12 than MMP-3, using nuclear magnetic resonance to monitor backbone dynamics and residue-sp...

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Detalhes bibliográficos
Main Authors: Liang, Xiangyang, Arunima, A., Zhao, Yingchu, Bhaskaran, Rajagopalan, Shende, Anuradha, Byrne, Todd S., Fleeks, Jeremy, Palmier, Mark O., Van Doren, Steven R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2010
Assuntos:
Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895380/
https://ncbi.nlm.nih.gov/pubmed/20655856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.04.002
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