HIV-1 Nef Binds a Subpopulation of MHC-I throughout Its Trafficking Itinerary and Down-regulates MHC-I by Perturbing Both Anterograde and Retrograde Trafficking

The HIV protein Nef is thought to mediate immune evasion and promote viral persistence in part by down-regulating major histocompatibility complex class I protein (MHC-I or HLA-I) from the cell surface. Two different models have been proposed to explain this phenomenon as follows: 1) stimulation of...

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Hlavní autoři: Yi, Ling, Rosales, Tilman, Rose, Jeremy J., Chaudhury, Bhabhadeb, Knutson, Jay R., Venkatesan, Sundararajan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945581/
https://ncbi.nlm.nih.gov/pubmed/20622010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.135947
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