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Phosphorylation of Tau at Thr(212), Thr(231), and Ser(262) Combined Causes Neurodegeneration
Abnormal hyperphosphorylation of the microtubule-associated protein Tau is a hallmark of Alzheimer disease and related diseases called tauopathies. As yet, the exact mechanism by which this pathology causes neurodegeneration is not understood. The present study provides direct evidence that Tau abno...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945578/ https://ncbi.nlm.nih.gov/pubmed/20663882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.110957 |
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