DHCR24 Knock-Down Induced Tau Hyperphosphorylation at Thr181, Ser199, Thr231, Ser262, Ser396 Epitopes and Inhibition of Autophagy by Overactivation of GSK3β/mTOR Signaling

Accumulating evidences supported that knock-down of DHCR24 is linked to the pathological risk factors of AD, suggesting a potential role of DHCR24 in AD pathogenesis. However, the molecular mechanism link between DHCR24 and tauopathy remains unknown. Here, in order to elucidate the relationship betw...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Bai, Xiaojing, Wu, Junfeng, Zhang, Mengqi, Xu, Yixuan, Duan, Lijie, Yao, Kai, Zhang, Jianfeng, Bo, Jimei, Zhao, Yongfei, Xu, Guoxiong, Zu, Hengbing
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8098657/
https://ncbi.nlm.nih.gov/pubmed/33967735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2021.513605
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