Effects of glucose on sorbitol pathway activation, cellular redox, and metabolism of myo-inositol, phosphoinositide, and diacylglycerol in cultured human retinal pigment epithelial cells.
Sorbitol (aldose reductase) pathway flux in diabetes perturbs intracellular metabolism by two putative mechanisms: reciprocal osmoregulatory depletion of other organic osmolytes e.g., myo-inositol, and alterations in NADPH/NADP+ and/or NADH/NAD+. The "osmolyte" and "redox" hypotheses predict seconda...
Sparad:
| I publikationen: | J Clin Invest |
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| Huvudupphov: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
American Society for Clinical Investigation
1994
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294524/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8201009/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117286 |
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