Effects of glucose on sorbitol pathway activation, cellular redox, and metabolism of myo-inositol, phosphoinositide, and diacylglycerol in cultured human retinal pigment epithelial cells.

Sorbitol (aldose reductase) pathway flux in diabetes perturbs intracellular metabolism by two putative mechanisms: reciprocal osmoregulatory depletion of other organic osmolytes e.g., myo-inositol, and alterations in NADPH/NADP+ and/or NADH/NAD+. The "osmolyte" and "redox" hypotheses predict seconda...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Autores principales:	Thomas, T P, Porcellati, F, Kato, K, Stevens, M J, Sherman, W R, Greene, D A
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 1994
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294524/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8201009/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117286
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