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Molecular Basis of the Selectivity of the Immunoproteasome Catalytic Subunit LMP2-Specific Inhibitor Revealed by Molecular Modeling and Dynamics Simulations
Given that immunoproteasome inhibitors are currently being developed for a variety of potent therapeutic purposes, the unique specificity of an α′,β′-epoxyketone peptide (UK101) towards the LMP2 subunit of the immunoproteasome (analogous to β5 subunit of the constitutive proteasome) has been investi...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945215/ https://ncbi.nlm.nih.gov/pubmed/20812720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp1058098 |
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