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Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements.

LAP (NF-IL6 or C/EBP beta), is a liver transcriptional activator protein that confers liver-specific gene expression. Because LAP has a characteristic phosphoacceptor sequence for cAMP-dependent protein kinase A (PKA), we tested if in vitro phosphorylation of LAP by PKA modulates its interaction wit...

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Bibliografische gegevens
Hoofdauteurs: Trautwein, C, van der Geer, P, Karin, M, Hunter, T, Chojkier, M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1994
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC294481/
https://ncbi.nlm.nih.gov/pubmed/8200992
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