Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements.

LAP (NF-IL6 or C/EBP beta), is a liver transcriptional activator protein that confers liver-specific gene expression. Because LAP has a characteristic phosphoacceptor sequence for cAMP-dependent protein kinase A (PKA), we tested if in vitro phosphorylation of LAP by PKA modulates its interaction wit...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Trautwein, C, van der Geer, P, Karin, M, Hunter, T, Chojkier, M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294481/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8200992/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117266
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