Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

Mutations in PARK2/Parkin, which encodes a ubiquitin E3 ligase, cause autosomal recessive Parkinson disease (PD). Here we show that the nonreceptor tyrosine kinase c-Abl phosphorylates tyrosine 143 of parkin, inhibiting parkin's ubiquitin E3 ligase activity and protective function. c-Abl is act...

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Main Authors: Ko, Han Seok, Lee, Yunjong, Shin, Joo-Ho, Karuppagounder, Senthilkumar S., Gadad, Bharathi Shrikanth, Koleske, Anthony J., Pletnikova, Olga, Troncoso, Juan C., Dawson, Valina L., Dawson, Ted M.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2010
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944759/
https://ncbi.nlm.nih.gov/pubmed/20823226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006083107
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