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ADS-J1 Inhibits HIV-1 Entry by Interacting with gp120 and Does Not Block Fusion-Active gp41 Core Formation

We had shown that virus resistance to ADS-J1 was associated with amino acid changes in the envelope glycoprotein, mostly located in the gp120 coding region. Time-of-addition and endocytic virus transfer assays clearly demonstrated that ADS-J1 behaved as a gp120 inhibitor. ADS-J1-resistant virus was...

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Autors principals: González-Ortega, Emmanuel, Mena, Maria-Pau, Permanyer, Marc, Ballana, Ester, Clotet, Bonaventura, Esté, José A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944580/
https://ncbi.nlm.nih.gov/pubmed/20643898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00359-10
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