Pharmacokinetics, Safety, and Tolerability of Voriconazole in Immunocompromised Children

The pharmacokinetics of voriconazole in children receiving 4 mg/kg intravenously (i.v.) demonstrate substantially lower plasma exposures (as defined by area under the concentration-time curve [AUC]) than those in adults receiving the same therapeutic dosage. These differences in pharmacokinetics bet...

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Main Authors: Walsh, Thomas J., Driscoll, Timothy, Milligan, Peter A., Wood, Nolan D., Schlamm, Haran, Groll, Andreas H., Jafri, Hasan, Arrieta, Antonio C., Klein, Nigel J., Lutsar, Irja
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944563/
https://ncbi.nlm.nih.gov/pubmed/20660687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00896-10
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