A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development

MDM2, a negative regulator of p53, is elevated in many cancers that retain wild-type p53. A single nucleotide polymorphism (SNP) in the human MDM2 promoter increases the affinity of Sp1 resulting in elevated MDM2 levels. We generated mice carrying either the MDM2(SNP309T) or the MDM2(SNP309G) allele...

Deskribapen osoa

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Xehetasun bibliografikoak
Egile Nagusiak: Post, Sean M., Quintás-Cardama, Alfonso, Pant, Vinod, Iwakuma, Tomoo, Hamir, Amir, Jackson, James G., Maccio, Daniela R., Bond, Gareth L., Johnson, David G., Levine, Arnold J., Lozano, Guillermina
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944041/
https://ncbi.nlm.nih.gov/pubmed/20832750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.07.010
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