A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development

MDM2, a negative regulator of p53, is elevated in many cancers that retain wild-type p53. A single nucleotide polymorphism (SNP) in the human MDM2 promoter increases the affinity of Sp1 resulting in elevated MDM2 levels. We generated mice carrying either the MDM2(SNP309T) or the MDM2(SNP309G) allele...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Post, Sean M., Quintás-Cardama, Alfonso, Pant, Vinod, Iwakuma, Tomoo, Hamir, Amir, Jackson, James G., Maccio, Daniela R., Bond, Gareth L., Johnson, David G., Levine, Arnold J., Lozano, Guillermina
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944041/
https://ncbi.nlm.nih.gov/pubmed/20832750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.07.010
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki