A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development

MDM2, a negative regulator of p53, is elevated in many cancers that retain wild-type p53. A single nucleotide polymorphism (SNP) in the human MDM2 promoter increases the affinity of Sp1 resulting in elevated MDM2 levels. We generated mice carrying either the MDM2(SNP309T) or the MDM2(SNP309G) allele...

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Main Authors: Post, Sean M., Quintás-Cardama, Alfonso, Pant, Vinod, Iwakuma, Tomoo, Hamir, Amir, Jackson, James G., Maccio, Daniela R., Bond, Gareth L., Johnson, David G., Levine, Arnold J., Lozano, Guillermina
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944041/
https://ncbi.nlm.nih.gov/pubmed/20832750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.07.010
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