Silencing RON Receptor Signaling Inhibits Growth and Sensitizes Pancreatic Cancer Xenografts to Gemcitabine

The RON receptor tyrosine kinase is overexpressed in pancreatic intraepithelial neoplasia (PanIN) and the majority of pancreatic cancers. Exposure of cultured pancreatic cancer cells to RON ligand enhances migration/invasion and apoptotic resistance and RON was recently identified as a key effector...

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Autori principali: Logan-Collins, Jocelyn, Thomas, Ryan M., Yu, Peter, Jaquish, Dawn, Mose, Evangeline, French, Randall, Stuart, William, McClaine, Rebecca, Aronow, Bruce, Hoffman, Robert, Waltz, Susan E., Lowy, Andrew M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943733/
https://ncbi.nlm.nih.gov/pubmed/20103639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0761
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